Applications of Polidocanol in Oral and Maxillofacial Surgery - A Literature Review
Review Article
DOI:
https://doi.org/10.56501/intjcraniomaxillofacsurgrehab.2022.582Keywords:
Sclerotherapy, Polidocanol, Local Inflammatory Signs, Oral Surgery, Vascular Lesions, TumorsAbstract
Head and neck vascular lesions can be classified based on their anatomic structure of origin as arterial, venous, and capillary lesions and malformations. These lesions are usually managed using sclerosing solutions before any surgical intervention. The process of morrhuate, Sodium injecting sclerosing agents into the blood vessels is known as sclerotherapy. The commonly used sclerosing agents are Sodium tetradecyl sulfate, Sodium ethanolamine oleate, and Polidocanol. Polidocanol is a synthetic long-chain fatty alcohol that possesses cytotoxic activity and causes lysis of erythrocytes, leukocytes, and plates. It also induces apoptosis by cell wall injury, calcium release, and nitric oxide production. Polidocanol was first used as an analgesic, but with time its use in the treatment of vascular malformations was observed. It is now considered a cost-effective treatment modality with lesser complications. The literature review aims at analyzing the existing literature evidence on the applications of polidocanol in oral and maxillofacial surgery.
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