Lymphoglandular bodies as useful morphological clue in diagnosis of Lymphoid malignancies- A Case Report

Sareen Rateesh; Garima Agarwal; Gajendra Nath Gupta

doi:10.56501/intjclinicopatholcorrel.v8i1.1036

Authors

Sareen Rateesh Department of Pathology & Transfusion Medicine, Santokba Durlabhji Hospital, Jaipur-302004, Rajasthan ,India.
Garima Agarwal Department of Pathology & Transfusion Medicine, Santokba Durlabhji Hospital, Jaipur-302004, Rajasthan ,India.
Gajendra Nath Gupta Department of Pathology & Transfusion Medicine, Santokba Durlabhji Hospital, Jaipur-302004, Rajasthan ,India.

DOI:

https://doi.org/10.56501/intjclinicopatholcorrel.v8i1.1036

Keywords:

Acute, Bone marrow biopsy, Lymphoglandular bodies, Leukemia, Giemsa stain

Abstract

Lymphoglandular bodies, observed as round basophilic cytoplasmic fragments on Giemsa stain, are linked with lymphoid malignancies, aiding in distinguishing lymphomas from other small round cell tumors. This case report underscores the diagnostic significance of Lymphoglandular bodies in Acute lymphoid leukemia diagnosis through bone marrow biopsy. We present a case of a 21-year-old male with chest pain and weakness. The bone marrow biopsy revealed a monomorphic cell population with a high nuclear cytoplasmic ratio, prompting immunomarker analysis that confirmed the presence of blasts as lymphoblasts, leading to the diagnosis of Acute lymphoid leukemia. The identification of Lymphoglandular bodies in bone marrow biopsy facilitated the diagnosis, as peripheral blood examination did not indicate the presence of blasts suggestive of leukemia. Literature on the role of Lymphoglandular bodies in lymphoma diagnosis is limited, with more emphasis on cytological preparations. Lymphoglandular bodies serve as an adjunct in differentiating between lymphoma and non-lymphoma malignancies, being more frequently associated with Malignant lymphoma. The study aim to prove Lymphoglandular bodies as useful morphological clue in diagnosis of Lymphoid malignancies.

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References

Jain S, Gajendra S, Sachdev R. Lymphoglandular bodies in bone marrow aspirate smears. Blood Res. 2017;52(1):7.https://doi.org/10.5045/br.2017.52.1.7

Stern RC, Liu K, Dodge RK, Elenitoba-Johnson KS, Layfield LJ. Significance of lymphoglandular bodies in bone marrow aspiration smears. Diagn Cytopathol. 2001;24(4):240–3. https://doi.org/10.1002/dc.1051

Pandey S, Gokden M, Kazemi NJ, Post GR. Hematolymphoid Malignancies Presenting with Spinal Epidural Mass and Spinal Cord Compression: A Case Series with Rare Entities. Ann Clin Lab Sci. 2019 Nov;49(6):818–28. https://doi.org/10.17511/jopm.2024.i01.01

Naemi K, Brynes RK, Reisian N, Johnston A, Dhillon R, Walavalkar V, et al. Benign lymphoid aggregates in the bone marrow: distribution patterns of B and T lymphocytes. Hum Pathol. 2013;44(4):512–20. https://doi.org/10.1016/j.humpath.2012.06.012

Murakami T, Kayano H, Itoh T, Shimizu Y, Ban S, Ogawa F, et al. Lymphoglandular bodies in malignant tumors: with special reference to histologic specimens. Ann Diagn Pathol. 2008;12(4):249–51. https://doi.org/10.1016/j.anndiagpath.2007.10.001

Kocjan G. Fine Needle Aspiration Cytology: Diagnostic Principles and Dilemmas. Springer Science & Business Media; 2006 Mar;60(3):335-36. https://doi.org/10.1136/jcp.2006.039875

Wood-Trageser MA, Lesniak AJ, Demetris AJ. Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring. Transplantation. 2019;103(7):1306–22. https://doi.org/10.1097/TP.0000000000002656

Provenzano E, Driskell OJ, O’Connor DJ, Rodriguez-Justo M, McDermott J, Wong N, et al. The important role of the histopathologist in clinical trials: challenges and approaches to tackle them. Histopathology. 2020;76(7):942–9. https://doi.org/10.1111/his.14099

Bavle RM. Lymphoglandular bodies. J Oral Maxillofac Pathol. 2014;18(3):334–5. https://doi.org/10.4103/0973-029X.151308

Rauh MJ, Good DJ. Bodies of evidence?Lymphoglandular bodies in aspirate smears of bone marrow involved by aggressivelarge B-cell lymphoma. Blood. 2014;123(24):3695.https://doi.org/10.1182/blood-2014-03-562579

Bonnard G, Babuty A, Collot R, Costes D, Drillaud N, Eveillard M, et al. Platelet features allow to differentiate immune thrombocytopenia from inherited thrombocytopenia. Ann Hematol. 2021;100(11):2677–82.https://doi.org/10.1007/s00277-021-04651-4

Schwock J, Geddie WR. Diagnosis of B-cell non-hodgkin lymphomas with small-/intermediate-sized cells in cytopathology. Patholog Res Int. 2012;32(2):164934. https://doi.org/10.1155/2012/164934

Flanders E, Kornstein MJ, Wakely PE Jr, Kardos TF, Frable WJ. Lymphoglandular bodies in fine-needle aspiration cytology smears. Am J Clin Pathol. 1993;99(5):566–9. https://doi.org/10.1093/ajcp/99.5.566

Bangerter M, Herrmann F, Griesshammer M, Gruss HJ, Hafner M, Heimpel H, et al. The abundant presence of Söderström bodies in cytology smears of fine-needle aspirates contributes to distinguishing high-grade non-Hodgkin’s lymphoma from carcinoma and sarcoma. Ann Hematol. 1997;74(4):175–8. https://doi.org/10.1007/s002770050278

Suzuki A, Hirokawa M, Ito A, Takada N, Higuchi M, Hayashi T, et al. Identification of Cytological Features Distinguishing Mucosa-Associated Lymphoid Tissue Lymphoma from Reactive Lymphoid Proliferation Using Thyroid Liquid-Based Cytology. Acta Cytol. 2018;62(2):93–8. https://doi.org/10.1159/000487502