Malignant Pleural Effusion Secondary to Clear cell Renal Cell Carcinoma- A Case Report

Ashutosh Jha; Meghashree Vishwanath; Prakashiny Sinnarajah; Prathipaa Rajavel; Pavithra Rajasekaran; Ramamoorthy Vedachalam

doi:10.56501/intjclinicopatholcorrel.v8i1.1063

Authors

Ashutosh Jha Department of Pathology, ACS Medical College and Hospitals, Poonamalle High Road, Velappanchavadi, Tiruvallur, Chennai, Tamil Nadu, 600077
Meghashree Vishwanath Department of Pathology, ACS Medical College and Hospitals, Poonamalle High Road, Velappanchavadi, Tiruvallur, Chennai, Tamil Nadu, 600077
Prakashiny Sinnarajah Department of Pathology, ACS Medical College and Hospitals, Poonamalle High Road, Velappanchavadi, Tiruvallur, Chennai, Tamil Nadu, 600077
Prathipaa Rajavel Department of Pathology, ACS Medical College and Hospitals, Poonamalle High Road, Velappanchavadi, Tiruvallur, Chennai, Tamil Nadu, 600077
Pavithra Rajasekaran Department of Pathology, ACS Medical College and Hospitals, Poonamalle High Road, Velappanchavadi, Tiruvallur, Chennai, Tamil Nadu, 600077
Ramamoorthy Vedachalam Department of Pathology, ACS Medical College and Hospitals, Poonamalle High Road, Velappanchavadi, Tiruvallur, Chennai, Tamil Nadu, 600077

DOI:

https://doi.org/10.56501/intjclinicopatholcorrel.v8i1.1063

Keywords:

Renal cell carcinoma, pleural effusion, clear cell carcinoma, metastases

Abstract

Renal cell carcinoma is the most common renal neoplasm. Its presentation is often very occult, and it may be discovered incidentally. It may present with the classic symptoms of back pain, flank pain, hematuria, or hypertension. Renal cell carcinoma may also present with malignant pleural effusion at diagnosis; however, it is very rare. Pleural effusion secondary to renal cell carcinoma constitutes only about 1% to 2% of all malignant pleural effusions. We report a case of 55-year-female who was a known case of Right side Renal cell carcinoma post operated and on chemotherapy suddenly presented in emergency department with breathlessness and chest pain. Chest X-ray demonstrated right-sided moderate pleural effusion; computed tomography (CT) reported bilateral effusion in the pleural cavity. CT-guided pleural thoracocentesis was performed. Cytology and cell block morphology showed clear cell type malignant tumor, leading to diagnosis of clear cell carcinoma in pleural fluid secondary to clear cell renal cell carcinoma. The study aim to discuss the Malignant pleural effusion secondary to Clear cell Renal cell carcinoma.

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References

Wasifuddin M, Ilerhunmwuwa N, Hakobyan N, et al. Malignant Pleural Effusion As the Initial Presentation of Renal Cell Carcinoma: A Case Report and Literature Review. Cureus.2023 15(4): e37128. https://doi.org/10.7759/cureus.37128.

Hutchinson A H, Fakhouri E W, Raudales J , Recurrent Large Volume Malignant Pleural Effusion in a Patient With Renal Cell Carcinoma. Cureus.2022; 13(2): e13593. https://doi.org/10.7759/cureus.13593.

Hofmann HS, Neef H, Krohe K, Andreev P, Silber RE. Prognostic factors and survival after pulmonary resection of metastatic renal cell carcinoma. Eur Urol. 2005;48(1):77-81. https://doi.org/10.1016/j.eururo.2005.03.004

Eckardt J, Ladegaard L, Licht PB: Isolated pleural metastases from renal cell carcinoma . Interact Cardiovasc Thorac Surg. 2011, 12:301-2. https://doi.org/10.1510/icvts.2010.245340 4.

Schiavoni V, Campagna R, Pozzi V, Cecati M, Milanese G, Sartini D, Salvolini E, Galosi AB, Emanuelli M. Recent advances in the management of clear cell renal cell carcinoma: Novel biomarkers and targeted therapies. Cancers. 2023 Jun 16;15(12):3207. https://doi.org/10.3390/ cancers15123207

Kiely JM. Hypernephroma—the internists tumor. Medical Clinics of North America. 1966 ,50(4):1067-83. https://doi.org/10.1016/s0025-7125(16)33152-2.

Jonasch E, Gao J, Rathmell WK. Renal cell carcinoma. Bmj. 349:g4797. https://doi.org/10.1136/bmj.g4797.

Studentova H, Rusarova N, Ondruskova A, Zemankova A, Student Jr V, Skanderova D, Melichar B. The Role of Cytoreductive Nephrectomy in Renal Cell Carcinoma with Sarcomatoid Histology: A Case Series and Review of the Literature. Current Oncology. 2022;29(8):5475-88. https://doi.org/10.3390/curroncol29080433

Shuch B, Zhang J. Genetic predisposition to renal cell carcinoma: implications for counseling, testing, screening, and management. Journal of Clinical Oncology. 2018;36(36):3560-6. https://doi.org/10.1200/JCO.2018.79.2523.

Gerlinger M, Horswell S, Larkin J, Rowan AJ, Salm MP, Varela I, Fisher R, McGranahan N, Matthews N, Santos CR, Martinez P. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nature genetics. 2014;46(3):225-33. https://doi.org/10.1038/ng.2891.

Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L. Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment. G Ital Nefrol. 2022; Jun 20;39(3):1.