Products of adaptive host immune response to viral agents in hyperthermia pediatric patients receiving malaria treatment and the immunoserologic status of their mothers

Abstract

Study Background: Hyperthermia is a manifestation of disease condition, which may also be as a result of immune response to the presence of infectious agent in the body that can be expressed in the serum/ plasma. At times, it is erroneously assumed for Plasmodium infection.
Aims and Objectives: This work was designed to express the products of adaptive host immune response to viral agents in hyperthermia pediatric patients receiving malaria treatment and the immunoserologic status of their mothers for effective management and diagnosis.
Materials and Methods: One hundred and four hyperthermia children aged 5–9 years receiving treatment in herbal homes were investigated as test, while one hundred age-matched children with normal body temperature were recruited from Owo and Ose local government areas as control subjects. Mothers of the hyperthermiachildrenwerealsostudied.AntihepatitisCvirus (HCV),humanimmunodeficiencyvirus (HIV) P24 antigen/antibody, anti-HBe, and HBeAg were determined by enzyme-linked immunosorbent assay, Plasmodium by Geimsa thick blood film, and acid-fast bacilli by Ziehl–Neelsen techniques.
Results: R Results obtained showed that the frequency of anti-HBe in mothers of hyperthermia patients (10.6% [11]) and in children with normal body temperature (9% [9]) was higher than the frequency of anti-HBe obtained in the hyperthermia herbal home children (4.8% [5]) while the frequency of HBeAg found in hyperthermia herbal home children (14.4% [15]) and their mothers (14.4% [15]) was higher than the results obtained in children with normal body temperature (4% [4]). The frequency of anti-HCV in herbal homehyperthermiachildren (2.9% [3])washigherthantheresultsobtainedintheirmothers (1.9% [2])and childrenwithnormalbodytemperature (1% [1]).TheHIVP24antigen/antibodyexpressedbythemothersof herbalhomehyperthermiachildren (3.85% [4])washighertheresultsobtainedintheirchildren (2.9% [3]), while none of the children with normal body temperature expressed HIV P24 antigen/antibody.

Conclusion:The frequency of Plasmodium in mothers of herbal home hyperthermia children (19.2% [20]) was higher than the results obtained in their hyperthermia children (9.6% [10]) and children with normal body temperature (3% [3]). The frequency of HIV in hyperthermia was 2.9% (3), while that of active/replicating hepatitis B virus (HBV) andHCVwas14.4% (HBeAg)and2.9% (anti-HCV),respectively.Onlymothersofhyperthermiaherbalhome