Primary nasopharyngeal non‐Hodgkin lymphoma

Abstract

A 12‐year‐old boy presented with the complaints of the nasal block for 2 months and progressive difficulty in swallowing. On magnetic resonance imaging, a large homogeneous nasopharyngeal mass is seen extending into the oropharynx showing no evidence of bony erosions, no necrosis, and no vascular invasion. A provisional diagnosis of lymphoma was considered. Differential diagnoses considered were nasopharyngeal carcinoma, rhabdomyosarcoma, and juvenile angiofibroma. Nasopharyngeal biopsy revealed sheets of atypical lymphoid cells infiltrating the fibrous and vascularized connective tissue stroma. The cells exhibited nuclear atypia and scanty neoplasm. The cells were strongly positive for leukocyte common antigen, CD20cy, and CD99a. A histopathological diagnosis of malignant non‐Hodgkin lymphoma – B type was made