Association of  Endogenous Metabolic End products & Clinicopathological traits of  Oral Squamous Cell Carcinoma

Priya R

doi:10.56501/intjclinicopatholcorrel.v6i2.536

Authors

Priya R Assistant Professor, Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, India.

DOI:

https://doi.org/10.56501/intjclinicopatholcorrel.v6i2.536

Keywords:

Creatinine, metastasis, OSCC, Urea

Abstract

Introduction: Oral squamous cell carcinoma (OSCC) is a widespread cancer and is associated with social and economic consequences. Clinico-pathological correlation improves patient survival and disease management. Our research intends to examine the relationships between OSCC and metabolic processes reflected by final catabolism products.

Methodology: In this cancer comparative retrospective analysis, metabolic byproducts in OSCC patients and healthy controls were compared. One way ANOVA analysis was done to record notable changes in OSCC patients by correlating along with disease's clinico-pathological traits.

Result: Serum Urea and creatinine level were determined in a total of 109 subjects, 55 diagnosed as OSCC and 54 healthy subjects who had been reported to our hospital for the past two years. OSCC and healthy patients revealed blood urea levels with significant correlation (p=0.000). Serum creatnine was insignificant between two groups (p<0.68). Blood urea and creatinine was insignificant with random blood sugar (p<0.205), negative correlation with habits (p<0.953) and significant with metastasis (p=0.000).

Conclusion: OSCC in advanced stages have nearing higher serum urea levels, and is associated with nodal metastases. Deregulation of protein catabolism processes may be associated with invasive characteristics of OSCC, enabling aggressive behaviour in OSCC.

Publication Facts

This article

Author statements

Data availability

N/A

16%

External funding

No

32%

Competing interests

N/A

11%

This journal

Other journals

Articles accepted

19%

33%

Days to publication

62

145

Indexed in

—

Editor & editorial board: profiles
Academic society: N/A
Publisher: MM Publications

References

Warnakulasuriya S, Greenspan JS. Textbook of Oral Cancer: Prevention, Diagnosis and Management. Springer Nature; 2020. 452 p.

Nethan ST, Gupta S, Warnakulasuriya S. Risk Factors for Oral Squamous Cell Carcinoma in the Indian Population. In: Routray S, editor. Microbes and Oral Squamous Cell Carcinoma: A Inflammation.Network Spanning Infection and Singapore: Springer Nature Singapore; 2022. p. 9–40.

Bonanthaya K, Panneerselvam E, Manuel S, Kumar VV, Rai A. Oral and Maxillofacial Surgery for the Clinician. Springer Nature; 2021. 2008 p.

Coletta RD, Yeudall WA, Salo T. Grand Challenges in Oral Cancers. Front Oral Health. 2020 Jun 9;1:3.

Navarro C, Ortega Á, Santeliz R, Garrido B, Chacín M, Galban N, et al. Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches. Pharmaceutics [Internet]. 2022 Jun 19;14(6).

Wei Z, Liu X, Cheng C, Yu W, Yi P. Metabolism of Amino Acids in Cancer. Front Cell Dev Biol. 2020;8:603837.

Schwameis R, Postl M, Bekos C, Hefler L, Reinthaller A, Seebacher V, et al. Prognostic value of serum creatine level in patients with vulvar cancer. Sci Rep. 2019 Jul 31;9(1):11129.

Yang M, Zhang Q, Ruan GT, Tang M, Zhang X, Song MM, et al. Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study. Front Oncol. 2021 Oct 7;11:710423.

Kornberg H. Krebs and his trinity of cycles. Nat Rev Mol Cell Biol. 2000 Dec;1(3):225–8.

Morris SM Jr. Regulation of enzymes of the urea cycle and arginine metabolism. Annu Rev Nutr. 2002 Jan 4;22:87–105.

Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, et al. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. 2017 Jun 1;546(7656):168–72.

Winter MC, Potter VA, Woll PJ. Raised serum urea predicts for early death in small cell lung cancer. Clin Oncol . 2008 Dec;20(10):745–50.