Association of  Endogenous Metabolic End products & Clinicopathological traits of  Oral Squamous Cell Carcinoma

Priya R

doi:10.56501/intjclinicopatholcorrel.v6i2.536

Authors

Priya R Assistant Professor, Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, India.

DOI:

https://doi.org/10.56501/intjclinicopatholcorrel.v6i2.536

Keywords:

Creatinine, metastasis, OSCC, Urea

Abstract

Introduction: Oral squamous cell carcinoma (OSCC) is a widespread cancer and is associated with social and economic consequences. Clinico-pathological correlation improves patient survival and disease management. Our research intends to examine the relationships between OSCC and metabolic processes reflected by final catabolism products.

Methodology: In this cancer comparative retrospective analysis, metabolic byproducts in OSCC patients and healthy controls were compared. One way ANOVA analysis was done to record notable changes in OSCC patients by correlating along with disease's clinico-pathological traits.

Result: Serum Urea and creatinine level were determined in a total of 109 subjects, 55 diagnosed as OSCC and 54 healthy subjects who had been reported to our hospital for the past two years. OSCC and healthy patients revealed blood urea levels with significant correlation (p=0.000). Serum creatnine was insignificant between two groups (p<0.68). Blood urea and creatinine was insignificant with random blood sugar (p<0.205), negative correlation with habits (p<0.953) and significant with metastasis (p=0.000).

Conclusion: OSCC in advanced stages have nearing higher serum urea levels, and is associated with nodal metastases. Deregulation of protein catabolism processes may be associated with invasive characteristics of OSCC, enabling aggressive behaviour in OSCC.

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