The Role of Magnesium Ions in Bone Formation and Regeneration: A Comprehensive Review

Authors

  • Janani S.P Tutor,R.V.S Dental College & Hospital, Sulur, Coimbatore.

DOI:

https://doi.org/10.56501/intjclinicopatholcorrel.v7i2.926

Keywords:

Magnesium, Bone remodelling, Bone regeneration, Osteogenesis, Good health and well being

Abstract

Magnesium ions play a pivotal role in bone formation and regeneration, influencing various cellular and molecular mechanisms. This comprehensive review aims to elucidate the multifaceted role of magnesium ions in bone health. The article explores how magnesium is involved in bone formation, its contributions to bone regeneration, its impact on molecular mechanisms, and its applications in orthopedic implants. An in-depth analysis of existing research provides valuable insights into the potential therapeutic applications of magnesium in bone-related disorders, shedding light on future directions for medical interventions.

References

Fiorentini D, Cappadone C, Farruggia G, Prata C. Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency. Nutrients [Internet]. 2021 Mar 30;13(4). Available from: http://dx.doi.org/10.3390/nu13041136

Ciosek Ż, Kot K, Kosik-Bogacka D, Łanocha-Arendarczyk N, Rotter I. The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue. Biomolecules [Internet]. 2021 Mar 28;11(4). Available from: http://dx.doi.org/10.3390/biom11040506

Castiglioni S, Cazzaniga A, Albisetti W, Maier JAM. Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients. 2013 Jul 31;5(8):3022–33.

Mammoli F, Castiglioni S, Parenti S, Cappadone C, Farruggia G, Iotti S, et al. Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D₃. Int J Mol Sci [Internet]. 2019 Jan 17;20(2). Available from: http://dx.doi.org/10.3390/ijms20020385

Katayama K, Povalko N, Yatsuga S, Nishioka J, Kakuma T, Matsuishi T, et al. New TRPM6 mutation and management of hypomagnesaemia with secondary hypocalcaemia. Brain Dev. 2015 Mar;37(3):292–8.

Zhou H, Liang B, Jiang H, Deng Z, Yu K. Magnesium-based biomaterials as emerging agents for bone repair and regeneration: from mechanism to application. Journal of Magnesium and Alloys. 2021 May 15;9(3):779–804.

Kim T, See CW, Li X, Zhu D. Orthopedic implants and devices for bone fractures and defects: Past, present and perspective. Engineered Regeneration. 2020 Jan 1;1:6–18.

Chakraborty Banerjee P, Al-Saadi S, Choudhary L, Harandi SE, Singh R. Magnesium Implants: Prospects and Challenges. Materials [Internet]. 2019 Jan 3;12(1). Available from: http://dx.doi.org/10.3390/ma12010136

Hung CC, Chaya A, Liu K, Verdelis K, Sfeir C. The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway. Acta Biomater. 2019 Oct 15;98:246–55.

Shan Z, Xie X, Wu X, Zhuang S, Zhang C. Development of degradable magnesium-based metal implants and their function in promoting bone metabolism (A review). J Orthop Translat. 2022 Sep;36:184–93.

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Published

2023-12-09

How to Cite

S.P, J. (2023). The Role of Magnesium Ions in Bone Formation and Regeneration: A Comprehensive Review. International Journal of Clinicopathological Correlation, 7(2), 34–37. https://doi.org/10.56501/intjclinicopatholcorrel.v7i2.926

Issue

Section

Review