Oral Carcinogenesis Unveiled: A Comprehensive Case Study on the Progression from Verrucous Carcinoma to Squamous Cell Carcinoma: Case Report

shaik abdul khader

doi:10.56501/intjclinicopatholcorrel.v7i2.975

Authors

shaik abdul khader Associate Professor,Department of Periodontology and Implantology,Dr. Shaik’s Dental clinic and Implant center, Broadway, Chennai-600001.

DOI:

https://doi.org/10.56501/intjclinicopatholcorrel.v7i2.975

Keywords:

Oral Carcinogenesis, Verrucous Carcinoma, Squamous Cell Carcinoma, Progression, Histopathological Analysis, Management, Oral Cancer

Abstract

This case report presents the clinical history, examination findings, and histopathological analysis of Mr. Sankar, a 40-year-old male patient, who reported pain and swelling in the lower left side of the jaw for the past 3 months. Initial examination revealed a whitish proliferative growth with papillary projections. The patient's history of tobacco and mawa chewing, cigarette smoking, and alcohol consumption for 25 years raised concerns about potential oral malignancies. The subsequent biopsy and histopathological investigation unveiled a progression from Verrucous Carcinoma to Squamous Cell Carcinoma.

References

Yellapurkar S, Boaz K, Manaktala N, KP N, Lewis AJ. Verrucous Carcinoma, A Very Well Differentiated Form of OSCC?-An Immunochemical Exploratory Study. The Open Dentistry Journal. 2023 Apr 6;17(1).

Messaoud NSB, Sioud S, Ayechi S, Youssef SB. Specificities of oral verrucous carcinoma: Case report and literature review. SAS J Surg. 2021 Oct 7;7(10):542–8.

Yanofsky VR, Mercer SE, Phelps RG. Histopathological variants of cutaneous squamous cell carcinoma: a review. J Skin Cancer. 2011;2011:210813.

Pal US, Maurya H, Yadav SK, Kumar V, Sowmya MV, Singh R. Protocol for Treatment of Oral Verrucous Carcinoma - A Systematic Review and Meta-Analysis. Ann Maxillofac Surg. 2023 Jul 31;13(1):88–94.

Kristofelc N, Zidar N, Strojan P. Oral verrucous carcinoma: a diagnostic and therapeutic challenge. Radiol Oncol. 2023 Mar 1;57(1):1–11.

Wong HH, Chu P. Immunohistochemical features of the gastrointestinal tract tumors. J Gastrointest Oncol. 2012 Sep;3(3):262–84.

Sharma P, Wadhwan V, Aggarwal P, Sharma A. Oral verrucous hyperplasia versus oral verrucous carcinoma: A clinicopathologic dilemma revisited using p53 as immunohistochemical marker. J Oral Maxillofac Pathol. 2016 Sep-Dec;20(3):362–8.

Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, et al. Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci. 2023 Sep 22;15(1):44.

Lee KD, Lu CH, Chen PT, Chan CH, Lin JT, Huang CE, et al. The incidence and risk of developing a second primary esophageal cancer in patients with oral and pharyngeal carcinoma: a population-based study in Taiwan over a 25-year period. BMC Cancer. 2009 Oct 20;9(1):1–5

Badwelan M, Muaddi H, Ahmed A, Lee KT, Tran SD. Oral Squamous Cell Carcinoma and Concomitant Primary Tumors, What Do We Know? A Review of the Literature. Curr Oncol. 2023 Mar 27;30(4):3721–34.