Genetic Overview Of Syndromic And Non Syndromic Tooth Agenesis - A Narrative Review Review Article

Abstract

Teeth agenesis is the condition where a defective tooth germ fails to develop into a tooth. Mutations in any of the delicate and balanced signaling cascades during tooth formation and development may cause arrested odontogenesis and/or other dental defects. Understanding the delicate gene regulation and molecular interactions among the cell is crucial for understanding the origin of teeth, its development and various genetic abnormalities associated with it. The mechanism of odontogenesis is now better known and well understood as a result of increasing advancement in technology and research, yet the complexity of the mechanism of tooth formation reveals newer knowledge which is found to be associated with the development of teeth. The aim of this narrative review is to acquire a deeper understanding about the genetic aspects that are responsible for the various causes and conditions associated with tooth agenesis.