Precursor lesions of gastric carcinoma: A histopathological study

Abstract

Introduction: Gastric cancer is common human malignant epithelial tumor associated with Helicobacter
pylori infection. H. pylori infection causes chronic active gastritis with progress to precursor lesions such as
atrophic gastritis and intestinal metaplasia which can progress to dysplasia and thus carcinoma may develop.
Aim of the Study: To study precursor lesions associated with different types of gastric carcinoma.
Materials and Methods: Eighty cases of gastric carcinoma were included in this study which showed adjacent
nonneoplastic gastric fragments. Hematoxylin- and eosin-stained slides were studied.
Results: Intestinal, diffuse, and mixed types of gastric carcinomas were seen in 67.5%, 28.75%, and 3.75% of
cases, respectively. H. pylori, chronic gastritis, atrophic gastritis, intestinal metaplasia, and dysplasia were
seen in 13.75%, 92.5%, 25%, 43.75%, and 22.5%, respectively.
Conclusions: In this study, we have described precursor lesions associated with gastric carcinoma as
described in the literature in the Indian population.