Clinicopathological correlation of radical prostatectomy specimens

Abstract

Introduction: Prostate cancer is the most common cancer in male, and histopathological examination of the prostatic tissue plays a very important role in diagnosis, prognosis, and management of patients with prostatic carcinoma.
Objective: To study the histopathological features of the radical prostatectomy specimens which decide prognosis and further management of patients with prostatic carcinoma and correlation with trucut biopsy. Materials and Methods: Fourteen radical prostatectomy specimens were evaluated which were grossed by standard techniques, and histopathological parameters were evaluated on hematoxylin and eosin-stained sections.
Results: Histopathologically acinar carcinoma is the most common type of prostatic carcinoma though there may be other types also. In this study only acinar carcinoma was found in all cases. Gleason pattern 3 and 4 were the predominant primary and secondary patterns respectively. Previous trucut biopsies result were available in 5 cases and in 4 cases grades were same in trucut biopsies and radical prostatectomy specimens however, in one case Gleason score in radical prostatectomy specimen was upgraded. Detailed histopathological examination of radical prostatectomy specimens according to prescribed guidelines is essential so that further management can be decided. The number of cases in this study are less more cases should be evaluated.
Conclusions: Detailed histopathological examination of radical prostatectomy specimens including extent into surrounding structures helps in prognosis and further management of patients with prostatic carcinoma.