A Rare Orbital Growth Posing a Diagnostic Dilemma: Extraskeletal Ewing Sarcoma

Case Report

Authors

  • Sara Aslam Fatima Junior Resident, Department of Pathology, JNMC, AMU, Aligarh
  • Shagufta Qadri Assistant Professor, Department of Pathology, JNMC, AMU, Aligarh
  • Sadaf Abbas Senior Resident, Department of Pathology, JNMC, AMU, Aligarh
  • Kiran Alam Professor, Department of Pathology, JNMC, AMU, Aligarh

DOI:

https://doi.org/10.56501/intjhistopatholinterpret.v13i2.1212

Keywords:

Extraskeletal Ewing sarcoma, soft tissue tumor, lower eyelid, primitive neuroectodermal tumor, Immunohistochemistry

Abstract

Extraskeletal Ewing Sarcoma (EES) is a rare soft tissue tumor that rarely occurs in the head and neck region and closely resembles Ewing sarcoma of the bone in its histomorphology. We present a case of EES involving the lower eyelid of the right eye in a 28-year-old woman. The patient underwent wide local excision of the tumor. The atypical location of the lesion initially obscured the diagnosis, which was ultimately confirmed through immunohistochemical analysis.

References

Iwamoto Y. Diagnosis and Treatment of Ewing’s Sarcoma. Jpn J Clin Oncol. 2007;37(2):79–89. doi:10.1093/jjco/hyl142.

Tural D, Molinas Mandel N, Dervisoglu S, Oner Dincbas F, Koca S, Colpan Oksuz D, et al. Extraskeletal Ewing’s Sarcoma Family of Tumors in Adults: Prognostic Factors and Clinical Outcome. Jpn J Clin Oncol. 2012;42(5):420–426. doi: 10.1093/jjco/hys064

Paksoy M, Altin G, Erdogan BA, Sekercan O, Bora F, Koca SB. A Rare Neck Mass: Extraskeletal Ewing’s Sarcoma. Int J Head Neck Surg. 2012;3(3):165–167. doi:10.5005/jp-journals-10001-1120

Li T, Goldberg RA, Becker B, McCann J. Primary orbital extraskeletal ewing sarcoma. Arch Ophthalmol. 2003;121(7):1049–52. doi:10.1001/archopht.121.7.1049

Lane KA, Katowitz JA. Ewing sarcoma presenting as a subconjunctival mass. Ophthal Plast Reconstr Surg. 2009;25:61–63. doi: 10.1097/IOP.0b013e31819361fd

Alio JL, Sales-Sanz M, Vaz MA, Barrancos C, Reguero ME, Diamantopoulus J, et al. Primary Extraosseous Ewing Sarcoma of the Orbit. Ophthal Plast Reconstr Surg. 2013;29(3):e91–e93. doi: 10.1097/IOP.0b013e3182771549

Somarouthu BS, Shinagare AB, Rosenthal MH, Tirumani H, Hornick JL, Ramaiya NH, et al. Multimodality imaging features, metastatic pattern and clinical outcome in adult extraskeletal Ewing sarcoma: experience in 26 patients. Br J Radiol. 2014;87(1038):20140123. doi:10.1259/bjr.20140123

Hornick JL. Practical soft tissue pathology. 2nd ed. Philadelphia: Elsevier; 2018.

Yoshida A, Sekine S, Tsuta K, Fukayama M, Furuta K, Tsuda H. NKX2.2 is a Useful Immunohistochemical Marker for Ewing Sarcoma. 10. Am J Surg Pathol. 2012;36(7):993–999. doi:10.1097/PAS.0b013e31824ee43c

Abboud A, Masrouha K, Saliba M, Haidar R, Saab R, Khoury N, et al. Extraskeletal Ewing sarcoma: Diagnosis, management and prognosis (Review). Oncol Lett. 2021;21(5):354. doi:10.3892/ol.2021.12615---10

Downloads

Published

2024-09-25

How to Cite

Sara Aslam Fatima, Shagufta Qadri, Sadaf Abbas, & Kiran Alam. (2024). A Rare Orbital Growth Posing a Diagnostic Dilemma: Extraskeletal Ewing Sarcoma: Case Report. International Journal of Histopathological Interpretation, 13(2), 17–21. https://doi.org/10.56501/intjhistopatholinterpret.v13i2.1212