Merkel Cells: A Review on Role of Merkel Cells in Histology and Disease

Abstract

The basic objective of this review is to understand the role of Merkel cells (MCs). MCs are neuroendocrine cells present in the epidermis of basal layers of vertebrates. The origin of MCs is controversial. They act as mechanoreceptors. MC carcinoma is known to be aggravating primary cutaneous neoplasm. Diagnosis of this is based on their staining. Radiation therapy and chemotherapy are given for such patients.