Calcifying Odontogenic Cyst: An Enigma

Amisha Jain; Himanshu Dhanodkar; Anjali Shujalpurkar; Gauri Motiwale

doi:10.56501/intjorofacres.v7i2.895

Authors

Amisha Jain Department of Oral and Maxillofacial Pathology, Modern Dental College and Hospital, Indore, Madhya Pradesh, India
Himanshu Dhanodkar Department of Oral and Maxillofacial Pathology, Sri Aurobindo College of Dentistry, Indore, Madhya Pradesh, India
Anjali Shujalpurkar Independent investigator, Bangalore, Karnataka, India
Gauri Motiwale Department of Oral and Maxillofacial Pathology, Sri Aurobindo College of Dentistry, Indore 452001, Madhya Pradesh

DOI:

https://doi.org/10.56501/intjorofacres.v7i2.895

Keywords:

Calcifying odontogenic cyst, odongenic cyst, review, COC, jaw, ghost cell

Abstract

The calcifying odontogenic cyst (COC), discovered in 1962, is a rare developmental odontogenic cyst clinically present as slow-growing swelling mainly in the anterior portion of the jaws, generally present in the second and sixth decades of life. It accounts for 0.3%–0.8% of odontogenic cysts. COC showed variations in clinical and radiographic features that are not pathognomic, whereas histomorphology forms exist in 3 patterns: benign cystic, solid (neoplastic), and aggressive (malignant) forms. The radiograph shows well-defined radiolucency with irregular masses, while the histopathologic features include a cystic lining with characteristic “Ghost” cells and immunohistochemical reactions positive for various enamel proteins.

References

Samir MC, Lamiae G, Bassima C. Calcifying odontogenic cyst of anterior maxillary: Case report and review. International Journal of Surgery Case Reports.2021;85(106267). https://doi.org/10.1016/j.ijscr.2021.106267.

Rastogi V, Pandilwar PK. Calcifying Epithelial Odontogenic Cyst Associated with Complex Odontome of Maxilla. J. Maxillofac. Oral Surg. 2013;12(1):85–89. https://doi.org/10.1007/s12663-010-0165-x.

Santos HBP, Morais EF, Moreira DGL, Neto LFA, Gomes PP, Freitas RA. Calcifying Odontogenic Cyst with Extensive Areas of Dentinoid: Uncommon Case Report and Update of Main Findings. Hindawi Case Reports in Pathology. 2018;8323215. https://doi.org/10.1155/2018/8323215.

Lagarde X, Sturque J, Fenelon M, Marteau JM, Fricain JC, Catros S. Calcifying odontogenic cyst: a report of two clinical cases. J Oral Med Oral Surg. 2019;25:36. https://doi.org/10.1051/mbcb/2019023.

Akshatha BK, Manjunath GS, Soundarya N. Calcifying odontogenic cyst associated with compound odontoma – A rare entity. J Oral Maxillofac Pathol 2023;27:S69-74. https://doi.org/10.4103/jomfp.jomfp_411_22.

Negi M, Puri A, Nangia R, Sepolia N. Proliferating ameloblastomatous calcifying odontogenic cyst: A rare case report. J Oral Res Rev 2020;12:91-7. https://doi.org/10.4103/jorr.jorr_22_19.

Shear M, Speight P. Cysts of the Oral and Maxillofacial Regions. 4th ed. Wiley-Blackwell; 2008.

Almazyad A, Almutairi M, Almadan N, Alamro M, Maki F, AlQuwayz TS et al. Frequency and Demographic Profile of Odontogenic Cysts in Riyadh, Saudi Arabia: Retrospective Multicenter Study. Diagnostics. 2023;13:355. https://doi.org/10.3390/diagnostics13030355

Arruda JA, Silva LV, Silva L, Monteiro JL, Álvares P, Silveira M, et al. Calcifying odontogenic cyst: A 26-year retrospective clinicopathological analysis and immunohistochemical study. J Clin Exp Dent. 2018;10(6):e542–7. https://doi.org/10.4317/jced.54528.

Negi BS, Danish I, Gupta P, Sabharwal R. Calcifying odontogenic cysts- A review. J Sci Soc 2020;47:3-7. https://doi.org/10.4103/jss.JSS_13_20.

Ahmad SA, Popli DB, Sircar K, Hasan S. Calcifying odontogenic cyst: Report of an uncommon entity with a brief literature review. J Oral Maxillofac Pathol 2022;26:131. https://doi.org/10.4103/jomfp.jomfp_358_21.

Shah U, Patel H, Pandya H, Dewan H, Bhavsar B, Steward E. Ameloblastomatous calcifying odontogenic cyst: A rare entity. Ann Maxillofac Surg 2018;8:108-15. https://doi.org/10.4103/ams.ams_206_17

Garg A, Malhotra R, Urs AB. Ghost cells unveiled: A comprehensive review. J Oral Biosci. 2022;64(2):202-209. https://doi.org/10.1016/j.job.2022.03.005.

Balaji SM, Rooban T. Calcifying odontogenic cyst with atypical features. Ann Maxillofac Surg 2012;2:82-5. https://doi.org/10.4103/2231-0746.95331.

Figueiredo NR, Meena M, Dinkar AD, Khorate M. Calcifying epithelial odontogenic cyst of the mandible. J Oral Res Rev 2014;6:57-60. https://doi.org/10.4103/2249-4987.152909.

Chandran A, Nachiappan S, Selvakumar R, Gunturu S, Lakshmi UV, Bharathi K, et al. Calcifying epithelial odontogenic cyst of maxilla: Report of a case and review and discussion on the terminology and classification. J Microsc Ultrastruct 2021;9:98-102. https://doi.org/10.4103/JMAU.JMAU_32_20.

Morgan PR. Odontogenic tumors: a review. Periodontology 2000. 2011;57:160–176. https://doi.org/10.1111/j.1600-0757.2011.00393.x

Irani S, Foroughi F. Histologic Variants of Calcifying Odontogenic Cyst: A Study of 52 Cases. J Contemp Dent Pract 2017;18(8):688-694. https://doi.org/10.5005/jp-journals-10024-2108

Wright JM, Vered M. Update from the 4th edition of the world health organization classification of head and neck tumours: Odontogenic and maxillofacial bone tumors. Head Neck Pathol. 2017;11(1):68-77. https://doi.org/10.1007/s12105-017-0794-1

Resende RG, Brito JAR, Souza LN, Gomez RS, Mesquita RA. Peripheral calcifying odontogenic cyst: A case report and Review of the literature. Head and Neck Pathol 2011;5:76–80. https://doi.org/10.1007/s12105-010-0213-3

Arruda JA, Silva LV, Silva L, Monteiro JL, Álvares P, Silveira M, et al. Calcifying odontogenic cyst: A 26-year retrospective clinicopathological analysis and immunohistochemical study. J Clin Exp Dent. 2018;10(6):e542-7. https://doi.org/10.4317/jced.54528.