BONE MASS AND THE MECHANOSTAT
Mini Review
DOI:
https://doi.org/10.56501/intjprosthorehab.v2i2.212Keywords:
Mechanostat, bone remodeling, microstrain, stress, windowAbstract
The Mechanostat is generally a term describing the way in which the mechanical loading influences the bone structure by changing
the mass (amount of bone) and the architecture (its arrangement) to provide a structure that resists the habitual loads with an
economical amount of material. As changes in the skeleton are accomplished by the processes of formation (bone growth) and
resorption (bone loss), the mechanostat models affect the influences on the skeleton by those processes, through their effector
cells, osteocytes, osteoblasts, and osteoclasts. The term was invented by Harold Frost: an orthopedic surgeon. The still-evolving
mechanostat hypothesis for bones inserts tissue-level realities into the former knowledge gap between bone's organ-level and celllevel realities. The mechanostat proposal is a seminal idea which fits diverse evidence but it requires critique and experimental
study. This current review describes in detail about the mechanostat theory and bone changes during the different phases
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Copyright (c) 2021 Nikita Singh, Varun Wadhwani, Vaishnavi Rajaraman
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